PerFem Forte™ (30)

The unique Santegra®’s product PerFem Forte™ is intended to help women who are facing a new stage in their life, which is called “menopause”.
Generations of women were awaiting it with fear, hoping that they will not suffer too much from the symptoms, concerned with the fundamental changes in the body’s functions. Nowadays women can look ahead with confidence and tranquility due to the new approach to the health maintenance during this difficult period.

Menopause is a natural event that normally occurs between the ages of 45 and 55.
You may begin to experience signs and symptoms of menopause well before your periods stop permanently. Once you haven’t had a period for 12 consecutive months, you’ve reached menopause.
The ovaries gradually slow their production of the female hormone estrogen and a woman begins to notice the effects this has on her body.
Many women experience headaches, hot flashes, trouble sleeping, tiredness, decreased sex drive, mood swings, irritability, depression which affect the quality of living.
Estrogen is essential for maintaining healthy cardiovascular system, cholesterol level and strong bones. The long-term effects of menopause can include: bone loss and eventual osteoporosis, changes in cholesterol levels and greater risk of heart disease.

It is very important to know how to care about your health in the period prior to the menopause:
• Active lifestyle, physical activity and fresh air will help to strengthen the cardiovascular system and bones.
• Healthy diet is essential for you, it is easy to gain extra pounds, but very difficult to get rid of them!
• Natural phytoestrogen supplementation can help to feel well and look well.
• Don’t forget about vitamins and minerals!
• And the most important thing – be self-confident! Life is good, it is going on and there are lots of wonderful and joyful events in front of you!

Several generations ago, few women lived beyond menopause. Today, you may spend as much as half of your life after menopause.
The new Santegra®’s product PerFem Forte™ will help you to prepare for the life change. Don’t wait for menopause, get armed against it!

PerFem Forte™ contains vitamin complex:

Vitamin E is one of the most potent antioxidants that protect body cells from destruction by free radicals. PerFem Forte™ contains vitamin E in a form of d-alpha tocopheryl succinate - the natural form of vitamin E, which is more active and better absorbed. Natural vitamin E may be as much as twice as bioavailable as synthetic vitamin E.

Tiamin (Vitamin B1) is called energy and optimism vitamin; it helps maintain healthy nervous system, essential for converting carbohydrate into energy, plays an important role in maintaining muscle tone; stabilizes the appetite. (2)

Riboflavin (Vitamin B2) functions as a coenzyme for many metabolic processes in the body, in red blood cell formation and nervous system function. Riboflavin is involved in energy production, essential for the immune system, for the eye health.

Niacin (Vitamin B3) plays a significant role in many aspects of energy metabolism and nervous system function. One of the most common uses for supplemental niacin is cholesterol regulation. Niacin lowers heart disease risk. (3, 4)

Pyridoxine (Vitamin B 6) is required for the balancing of hormonal changes in women as well as assisting the immune and nervous systems and the growth of new cells. It is also used in the metabolism of proteins, fats and carbohydrates. Because vitamin B6 is involved in the synthesis of neurotransmitters in the brain and nerve cells, it is frequently recommended as a nutrient to support mental function (mood).

Folic acid (Vitamin В9) plays an important role in DNA and RNA synthesis, production of red blood cells, for the nervous system and cardiovascular health.
Vitamin B9 is essential for maintaining normal homocysteine level. Recent studies in elderly people suggest a link between folic acid, homocysteine, ageing, depression, and dementia, including Alzheimer’s disease. Folate concentrations in serum and cerebrospinal fluid fall and plasma homocysteine rises with age, perhaps contributing to the ageing process. (5)
Folic acid is important in the nervous system at all ages, it affects mood, cognitive and social function, but in elderly people deficiency contributes to ageing brain processes, increases the risk of Alzheimer’s disease and dementia.
Some studies have suggested that there is a relationship between elevated homocysteine levels and cardiovascular disease.
Folate supplementation has been shown to normalize increased homocysteine blood levels. (6)

Vitamin B12 (cyanocobalamin) is essential for proper energy metabolism, cell replication, for the genetic material in cells known as DNA and RNA, blood cell formation, nervous system maintenance and heart health.
Vitamin B12 acts with folic acid and vitamin B6 to control homocysteine levels. An excess of homocysteine is associated with an increased risk of heart disease, stroke, and potentially other diseases such as osteoporosis and Alzheimer’s disease.
Vitamin B12 deficiency causes fatigue and is associated with cognitive impairment.
A preliminary study found that postmenopausal women who were in the lowest one-fifth of vitamin B12 consumption had an increased risk of developing breast cancer. (7)

Selenium is a potent antioxidant, which defends body cells from free radical damage, it is essential for the immune system (8), has cardioprotective activity, and may help protect the body from cancer. (9)

PerFem Forte™ contains also standardized amount of isoflavones from GMO-Free soybean extract and red clover extract (25.5 mg aglycone isoflavones).
Isoflavones are associated with many health benefits, because they can protect against hormone-related disorders.

The chemical structure of isoflavones is similar to that of our own estrogen. Because of this similarity, isoflavones can interfere with the action of our own estrogen.
The risks of excess estrogen can be lowered in this way. Isoflavones can also increase the estrogen activity.
When during menopause the body’s natural level of estrogen drops, isoflavones can compensate this, easing menopause symptoms.

The soy isoflavones are responsible for most of the soy health benefits. The most important soy isoflavones are genistein and daidzein. Isoflavones can be represented in the glycoside or aglycone forms. In soybeans isoflavones occur mostly in glycoside form, which doesn’t cause estrogen response of the cells in contrast to aglycone isoflavones.
Glucoside form isoflavones must be converted into the aglycone form in the intestines before they can be absorbed. The efficiency of this conversion can greatly affect the amount of isoflavone actually absorbed into the body.
Interesting fact – the population of Southeast Asia (China, Japan, Korea etc.) has lower risk of cancer and heart diseases than in Europe and America. People in these countries rarely have osteoporosis, despite their low consumption of dairy products. Eastern women have less severe menopause symptoms (such as hot flashes). Why? Some scientists suggest that one of the reasons is the peculiarity of the diet of the population in Southeast Asia, in particular the large consumption of fermented soy foods. During fermentation process glucosides are converted into aglycone isoflavones, which are highly bioavailable.
Soy isoflavones appear to reduce cardiovascular disease risk. Isoflavones inhibit the plaque formation on the arteries walls. A review of controlled studies on soy and heart disease concluded that soy is definitely effective for improving cholesterol profile.
Soy isoflavones help in the preservation of the bone substance and help prevent osteoporosis. Population-based studies show a strong association between consumption of isoflavones and a reduced risk of cancer.
Recent studies have found that soy isoflavones can reduce menopause symptoms such as hot flushes.

PerFem Forte™ contains fermented form of isoflavones - aglycone isoflavones, which are absorbed much more completely and quickly, and are the most effective form of isoflavones.

Another beneficial natural ingredient in PerFem Forte™ is Black cohosh root extract, standardized to 8% triterpene glycosides. Studies have demonstrated that Black cohosh, when standardized to the terpene glycoside fraction, appears to be effective in alleviating menopausal symptoms.

The herb is native to North America. Black cohosh was originally used by Native American people in the treatment of many conditions, especially gynecologic disorders.

The American College of Obstetrics and Gynecology guidelines on the use of botanicals for the management of menopausal symptoms support the use of Black cohosh for up to six months, especially in treating the symptoms of sleep and mood disturbance, and hot flushes. (13)

Per 1 packet:

Vitamin E (as d-alpha-tocopheryl succinate) - 15 IU,
Thiamin (as thiamin mononitrate) - 1 mg,
Riboflavin - 1 mg, Niacin (as niacinamide) - 10 mg,
Vitamin B6 (as pyridoxine HCl) - 3 mg,
Folate - 200 mcg,
Vitamin B12 (as cyanocobalamin) - 3 mcg,
Selenium (as selenium + GMP™) - 35 mcg,
Fermented (aglycone) VDF Isoflavones™ (from organic GMO-Free soybean extract and GMO-Free red clover extract (aerial parts))- 25.5 mg,
Black cohosh (Cimicifuga foetida) (12:1) root extract [(8% triterpene glycosides (as 27-deoxyactein)] (equivalent to 150 mg of crude herb) - 12.5 mg.

As a dietary supplement take 1 capsule twice daily in the morning and in the evening with a large glass of water with meals.

Individual intolerance. Do not use this product if pregnant or nursing.